What question did this study set out to answer?

To identify factors driving the high incidence and prophylaxis resistance of venous thrombosis and pulmonary embolism in patients undergoing total hip replacement compared to general surgery.

July 1, 1979Journal of Bone and Joint SurgeryOpen Access

The effect of total hip replacement and general surgery on antithrombin III in relation to venous thrombosis.

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Authors

SGSanford N. GitelScripps Research Institute ESE A SalvatiHospital for Special Surgery SWStanford WesslerVascular / Pulmonary Vascular

Discussion

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Implication

Comparative study reveals greater antithrombin III depletion in total hip arthroplasty, indicating profound clotting activation linked to elevated thrombosis risk.

Key Points

To identify factors driving the high incidence and prophylaxis resistance of venous thrombosis and pulmonary embolism in patients undergoing total hip replacement compared to general surgery.
Compared 21 patients undergoing total hip arthroplasty against 14 patients undergoing general surgical procedures.
Measured perioperative and postoperative antithrombin III depletion as a biomarker of coagulation cascade activation.
Assessed deep vein thrombosis incidence in hip-replacement patients using post-procedure venography.
Total hip arthroplasty patients exhibited a significantly greater decrease in antithrombin III both intraoperatively and postoperatively compared with general surgery patients (p < 0.05).
Venographic evaluation revealed recent thrombosis in 73% of hip-replacement patients, with 60% localized as discontinuous femoral-vein thrombi.

Cite This Study

Gitel et al. (1979) studied this question.

synapsesocial.com/papers/6a8361aab5896a05cedfa9e9 https://doi.org/10.2106/00004623-197961050-00002

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July 1, 1979Journal of Bone and Joint SurgeryOpen Access

The effect of total hip replacement and general surgery on antithrombin III in relation to venous thrombosis.

View Full Paper

Ask AI

Bookmark

Authors

SGSanford N. GitelScripps Research Institute ESE A SalvatiHospital for Special Surgery SWStanford WesslerVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Comparative study reveals greater antithrombin III depletion in total hip arthroplasty, indicating profound clotting activation linked to elevated thrombosis risk.

Key Points

To identify factors driving the high incidence and prophylaxis resistance of venous thrombosis and pulmonary embolism in patients undergoing total hip replacement compared to general surgery.
Compared 21 patients undergoing total hip arthroplasty against 14 patients undergoing general surgical procedures.
Measured perioperative and postoperative antithrombin III depletion as a biomarker of coagulation cascade activation.
Assessed deep vein thrombosis incidence in hip-replacement patients using post-procedure venography.
Total hip arthroplasty patients exhibited a significantly greater decrease in antithrombin III both intraoperatively and postoperatively compared with general surgery patients (p < 0.05).
Venographic evaluation revealed recent thrombosis in 73% of hip-replacement patients, with 60% localized as discontinuous femoral-vein thrombi.

Cite This Study

Gitel et al. (1979) studied this question.

synapsesocial.com/papers/6a8361aab5896a05cedfa9e9 https://doi.org/10.2106/00004623-197961050-00002

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