Why the study?
Does total hip replacement induce a prolonged hypercoagulable state as measured by antithrombin III levels?
Population
Patients undergoing total hip replacement
Comparison
Total hip replacement vs Preoperative baseline
Design
Cohort
Follow-up
24 hours after surgery
Authors
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Transient ATIII decline after femoral neck division does not support prolonged hypercoagulability; leaves open multifactorial VTE mechanisms after THR.
Does total hip replacement induce a prolonged hypercoagulable state as measured by antithrombin III levels?
The fall in antithrombin III after total hip replacement is transient and resolves by 24 hours, suggesting venous thrombosis is not solely due to hypercoagulability.
McNally et al. (1996) studied this question.
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