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January 1, 1983Thrombosis and Haemostasis

Pre- and Postoperative Levels of Antithrombin III with Special Reference to Thromboembolism After Total Hip Replacement

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Why the study?

Does dextran 70 compared to low dose heparin combined with dihydroergotamine prevent thromboembolism in patients undergoing total hip replacement?

Population

207 patients undergoing total hip replacement

Comparison

Thromboembolic prophylaxis with dextran 70 vs Low dose heparin combined with dihydroergotamine

Design

RCT, randomly allocated

Follow-up

postoperative

Authors

HFHans FredinUppsala University HospitalBNBengt NilssonKarolinska University HospitalBRB. RosbergLund University

Discussion

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Implication

Both regimens yield ~51% thromboembolism rates without difference; challenges adequacy of either for hip replacement and extends call for superior prophylaxis.

Structured PICO

Does dextran 70 compared to low dose heparin combined with dihydroergotamine prevent thromboembolism in patients undergoing total hip replacement?

P
Population
207 patients undergoing total hip replacement
I
Intervention
Thromboembolic prophylaxis with dextran 70
C
Comparator
Low dose heparin combined with dihydroergotamine
O
Outcome
Deep vein thrombosis determined by phlebography of the operated leg or pulmonary embolism diagnosed with perfusion/ventilation scintigraphyhard clinical

In patients undergoing total hip replacement, thromboembolic prophylaxis with dextran 70 or low dose heparin combined with dihydroergotamine showed no significant difference in the incidence of DVT or PE.

Cite This Study

Fredin et al. (1983) studied this question.

synapsesocial.com/papers/6a8361aab5896a05cedfa9e8https://doi.org/10.1055/s-0038-1657352

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antithrombin III prophylaxis of venous thromboembolic disease after total hip or total knee replacement1989 · 19 citations
  2. 2Hypercoagulability after Total Hip Replacement1996 · 2 citations
  3. 3Thrombin-Antithrombin III Complexes in the Prediction of Deep Vein Thrombosis Following Total Hip Replacement1989 · 37 citations
  4. 4Pre-operative Plasma Levels of Thrombin-Antithrombin III Complexes Correlate with the Development of Venous Thrombosis after Major Hip or Knee Surgery1995 · 44 citations
  5. 5Value of Thrombin-Antithrombin III Complexes in Major Orthopedic Surgery: Relation to the Onset of Venous Thromboembolism1999 · 6 citations