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January 1, 1989Thrombosis and Haemostasis

Thrombin-Antithrombin III Complexes in the Prediction of Deep Vein Thrombosis Following Total Hip Replacement

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Why the study?

Does thrombin-antithrombin III complex immunoassay accurately predict the development of deep vein thrombosis in patients following elective total hip surgery?

Population

196 consecutive patients who underwent elective total hip surgery

Comparison

Thrombin-antithrombin III complex immunoassay… vs Contrast venography on the tenth postoperative day

Design

Cohort

Follow-up

10 days

Authors

JHJ A HoekState University of MedanMNMichael T. NurmohamedReadeJCJ W ten CateDuke University

Discussion

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Implication

T-AT complex lacks utility for DVT prediction after hip surgery; leaves open whether alternative biomarkers warrant prospective evaluation.

Structured PICO

Does thrombin-antithrombin III complex immunoassay accurately predict the development of deep vein thrombosis in patients following elective total hip surgery?

P
Population
196 consecutive patients who underwent elective total hip surgery
I
Intervention
Thrombin-antithrombin III (T-AT) complex immunoassay assessed on the first, fourth, and tenth postoperative day
C
Comparator
Contrast venography on the tenth postoperative day
O
Outcome
Diagnostic accuracy for the development of deep vein thrombosis (DVT)surrogate

Postoperative determination of T-AT complex plasma concentrations has no clinical utility in predicting postoperative DVT in hip surgery patients.

Cite This Study

Hoek et al. (1989) studied this question.

synapsesocial.com/papers/6a9174782e07877a42ab4e7ahttps://doi.org/10.1055/s-0038-1647115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Value of Thrombin-Antithrombin III Complexes in Major Orthopedic Surgery: Relation to the Onset of Venous Thromboembolism1999 · 6 citations
  2. 2Pre-operative Plasma Levels of Thrombin-Antithrombin III Complexes Correlate with the Development of Venous Thrombosis after Major Hip or Knee Surgery1995 · 44 citations
  3. 3Thrombin antithrombin complex concentration as an early predictor of deep vein thrombosis after total hip arthroplasty and total knee arthroplasty2022 · 27 citations
  4. 4Pre- and Postoperative Levels of Antithrombin III with Special Reference to Thromboembolism After Total Hip Replacement1983 · 28 citations
  5. 5Clinical Utility of Prothrombin Fragment 1+2, Thrombin Antithrombin III Complexes and D-dimer Measurements in the Diagnosis of Deep Vein Thrombosis following Total Hip Replacement1998 · 23 citations