January 1, 1995Thrombosis and Haemostasis
Pre-operative Plasma Levels of Thrombin-Antithrombin III Complexes Correlate with the Development of Venous Thrombosis after Major Hip or Knee Surgery
Key result
Pre-operative plasma TAT levels were significantly higher in patients who developed DVT after major hip or knee surgery compared to those who did not (5.7 vs 4.1 micrograms/l; p=0.035).
Why the study?
Do pre-operative plasma levels of thrombin-antithrombin III (TAT) predict the development of deep vein thrombosis in patients undergoing major hip or knee surgery?
Population
98 consecutive patients undergoing elective major hip or knee surgery at a tertiary-care referral centre…
Design
Cohort
Follow-up
prior to discharge
Authors
Discussion
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Member takes
Implication
Elevated pre-operative TAT was associated with post-operative DVT after hip/knee surgery; leaves open utility for risk stratification pending prospective validation.
Study Design
Type
Cohort (n=98)
Multicenter
No
Structured PICO
Do pre-operative plasma levels of thrombin-antithrombin III (TAT) predict the development of deep vein thrombosis in patients undergoing major hip or knee surgery?
P
Population
98 consecutive patients undergoing elective hip or knee surgery who received standard DVT prophylaxis.
E
Exposure
Measurement of plasma thrombin-antithrombin III (TAT) levels two weeks pre-operatively.
O
Outcome
Development of deep vein thrombosis (proximal or calf) assessed by contrast venography prior to discharge.hard clinical
Main Result
p-value: p=0.035
Pre-operative plasma TAT levels correlate with the risk of developing DVT after major orthopedic surgery, potentially aiding in risk stratification.
Cite This Study
Ginsberg et al. (1995) conducted a cohort in Major hip or knee surgery (n=98). Pre-operative plasma TAT levels vs. Lower TAT levels was evaluated on Development of deep vein thrombosis (DVT) (p=0.035). Pre-operative plasma TAT levels were significantly higher in patients who developed DVT after major hip or knee surgery compared to those who did not (5.7 vs 4.1 micrograms/l; p=0.035).