Key result
High preoperative levels of coagulation activation markers, such as F1+2, were associated with a higher frequency of DVT after total hip replacement compared to low levels (65.7% vs 18.8%; P<0.001).
Why the study?
Do preoperative levels of F1+2, TAT, and D-dimer predict the risk of deep vein thrombosis in patients undergoing total hip replacement?
Population
159 patients undergoing total hip replacement, part of an international study.
Comparison
High preoperative levels of coagulation… vs Low preoperative levels of the same coagulation…
Design
Cohort, Patients were randomized to receive 10, 15 or 20 mg desirudin bid or…
Follow-up
11 days
Authors
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May aid preoperative DVT risk stratification in hip replacement; leaves open whether targeting high F1+2 improves outcomes.
RCT (n=159)
randomized
Yes
Do preoperative levels of F1+2, TAT, and D-dimer predict the risk of deep vein thrombosis in patients undergoing total hip replacement?
Absolute Event Rate: 65.7% vs 18.8%
p-value: p=<.001
Preoperative levels of coagulation activation markers (F1+2, TAT, and D-dimer) can help identify patients at high risk for developing DVT after total hip replacement despite prophylaxis.
Cofrancesco et al. (1997) conducted an RCT in deep vein thrombosis (DVT) after elective hip surgery (n=159). High preoperative levels of F1+2, TAT, and D-dimer vs. Low preoperative levels was evaluated on deep vein thrombosis (DVT) detected by postoperative venography (p=<.001). High preoperative levels of coagulation activation markers, such as F1+2, were associated with a higher frequency of DVT after total hip replacement compared to low levels (65.7% vs 18.8%; P<0.001).
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