Key result
Five-week LMWH prevents the delayed surge in haemostatic activation vs 1-week therapy after hip arthroplasty.
Why the study?
Tissue injury during total hip arthroplasty activates the haemostatic system, and the influence of prolonged thromboprophylaxis on haemostatic markers is unclear.
Does prolonged thromboprophylaxis with dalteparin for 5 weeks reduce postoperative activation of the haemostatic system compared to 1 week of dalteparin in patients undergoing total hip arthroplasty?
Population
Patients undergoing total hip arthroplasty
Comparison
Dalteparin once daily for 5 weeks vs placebo after 1-week dalteparin treatment
Design
Multicentre randomized controlled trial
Follow-up
35 days
Authors
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May support extended LMWH after hip arthroplasty to blunt late activation; leaves open clinical VTE impact.
RCT
randomized
Yes
Does prolonged thromboprophylaxis with dalteparin for 5 weeks reduce postoperative activation of the haemostatic system compared to 1 week of dalteparin in patients undergoing total hip arthroplasty?
Prolonged thromboprophylaxis with dalteparin for 5 weeks significantly attenuates late postoperative activation of the haemostatic system compared to a standard 1-week regimen in patients undergoing total hip arthroplasty.
Birthe Søgaard Andersen (2009) conducted an RCT in Total hip arthroplasty. Low molecular weight heparin (dalteparin) vs. 1-week LMWH followed by placebo was evaluated on Markers of haemostatic activity (F1+2, TAT, FbDP, SF). Prolonged thromboprophylaxis with LMWH for 5 weeks prevented the significant increase in haemostatic markers seen on day 35 in patients receiving only 1 week of LMWH after total hip arthroplasty.
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