Key result
Initiating 5000 IU dalteparin 12 hours before versus 6 hours after total hip arthroplasty resulted in no significant differences in coagulation and fibrinolysis biomarkers.
Why the study?
Does initiating 5000 IU dalteparin subcutaneously 12 hours before surgery improve plasma coagulation and fibrinolysis biomarkers compared to 6 hours after surgery in patients undergoing cemented total hip arthroplasty?
Population
20 patients undergoing cemented total hip arthroplasty (THA)
Comparison
First dose of 5000 IU dalteparin subcutaneously… vs First dose of 5000 IU dalteparin subcutaneously…
Design
RCT, Randomly assigned
Follow-up
Up to 6 days after surgery
Authors
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No biomarker differences by dalteparin timing; confirms equivalent coagulation activation whether started pre- or postoperatively.
RCT (n=20)
Does initiating 5000 IU dalteparin subcutaneously 12 hours before surgery improve plasma coagulation and fibrinolysis biomarkers compared to 6 hours after surgery in patients undergoing cemented total hip arthroplasty?
Activation of coagulation and fibrinolysis by operative trauma in total hip arthroplasty is similar whether dalteparin prophylaxis is initiated 12 hours before or 6 hours after surgery.
Borgen et al. (2013) conducted an RCT in Total hip arthroplasty (n=20). Dalteparin 12 hours before surgery vs. Dalteparin 6 hours after surgery was evaluated on Plasma coagulation (F1+2) and fibrinolytic activity (PAP and D-dimer) biomarkers. Initiating 5000 IU dalteparin 12 hours before versus 6 hours after total hip arthroplasty resulted in no significant differences in coagulation and fibrinolysis biomarkers.
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