Why the study?
Does postoperative initiation of dalteparin reduce blood loss and transfusions compared to preoperative initiation in patients undergoing total hip arthroplasty?
Population
599 patients undergoing total hip arthroplasty (THA) (two cohorts of 298 and 301 patients)
Comparison
Dalteparin sodium 2500 IU subcutaneously 6 hours… vs Dalteparin sodium 5000 IU subcutaneously the…
Design
Cohort
Follow-up
6 months
Authors
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Postoperative dalteparin initiation may limit blood loss in THA; leaves open whether RCTs will confirm net benefit before changing practice.
Does postoperative initiation of dalteparin reduce blood loss and transfusions compared to preoperative initiation in patients undergoing total hip arthroplasty?
Initiating dalteparin 6 hours postoperatively rather than preoperatively in total hip arthroplasty significantly reduces blood loss and transfusion requirements without increasing thromboembolic events.
Borgen et al. (2010) studied this question.
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