Why the study?
Does dalteparin 5000 XaI units reduce deep vein thrombosis compared to 2500 XaI units in patients undergoing elective general surgery?
Population
2070 patients undergoing elective general surgery for malignant and benign abdominal disease.
Comparison
Dalteparin 5000 XaI units once-daily, started in… vs Dalteparin 2500 XaI units once-daily, started in…
Design
RCT, randomized, double-blind
Follow-up
30 days
Authors
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Supports higher-dose dalteparin for DVT prophylaxis in elective general surgery; extends RCT evidence on LMWH dosing.
Does dalteparin 5000 XaI units reduce deep vein thrombosis compared to 2500 XaI units in patients undergoing elective general surgery?
Dalteparin 5000 XaI units provides superior DVT prophylaxis compared to 2500 XaI units in patients undergoing elective general surgery, with a small increase in bleeding risk.
Bergqvist et al. (1995) studied this question.
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