Why the study?
Does total hip arthroplasty activate thrombin generation and fibrinolysis during and immediately after surgery?
Population
10 patients aged 16-62 years undergoing primary total hip arthroplasty with insertion of an uncemented…
Design
Cohort
Follow-up
4 hours postoperatively
Authors
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Thrombin generation and fibrinolysis activate during THA; hypothesis-generating for prophylaxis timing, needs prospective confirmation.
Does total hip arthroplasty activate thrombin generation and fibrinolysis during and immediately after surgery?
Thrombin generation is activated during total hip arthroplasty with subsequent fibrin degradation, providing pathophysiological evidence that the timing of antithrombotic prophylaxis initiation is critical.
Reikerås et al. (2006) studied this question.
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