Key result
Total hip arthroplasty increased prothrombin fragment F1+2 in both plasma and urine during surgery, though no correlation between plasma and urine levels was found later in the postoperative period.
Why the study?
How do prothrombin fragment F1+2 levels in plasma and urine change and correlate during and after total hip arthroplasty?
Population
Patients undergoing total hip arthroplasty (THA)
Design
Cohort
Follow-up
6 days postoperatively
Authors
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F1+2 rises during THA may flag intraoperative thrombin generation; leaves open urine as a noninvasive postoperative marker pending validation.
Observational
How do prothrombin fragment F1+2 levels in plasma and urine change and correlate during and after total hip arthroplasty?
While F1+2 increases in both plasma and urine during operative trauma, their levels do not correlate in the later postoperative period.
Borgen et al. (2017) conducted an observational in Total hip arthroplasty. Total hip arthroplasty was evaluated on Time course and correlation of prothrombin fragment (F1 + 2) in plasma and urine. Total hip arthroplasty increased prothrombin fragment F1+2 in both plasma and urine during surgery, though no correlation between plasma and urine levels was found later in the postoperative period.
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