Key result
Total hip replacement is linked to ~10-fold higher CRP on postoperative day one.
Why the study?
The time-course and levels of systemic inflammatory and hemostasis markers in the early postoperative period after total hip replacement were not well characterized.
Does total hip replacement increase systemic inflammatory and procoagulant markers in the early postoperative period?
Observational (n=70)
Does total hip replacement increase systemic inflammatory and procoagulant markers in the early postoperative period?
Absolute Event Rate: 68.5% vs 6.8%
p-value: p=<0.001
Total hip replacement induces a significant and progressive increase in systemic inflammatory and procoagulant markers up to 5 days post-surgery, potentially increasing the risk of cardiovascular thromboembolic events.
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Post-THR CRP surge may signal heightened early thromboembolic risk; leaves open whether anti-inflammatory strategies reduce events.
Poredoš et al. (2021) conducted an observational in Total hip replacement (n=70). Total hip replacement vs. Preoperative baseline (POD 0) was evaluated on C-reactive protein (CRP) levels on postoperative day 1 (p=<0.001). Total hip replacement provoked a significant increase in systemic inflammatory markers, including CRP (68.5 vs 6.8 μg/mL, p<0.001) on postoperative day 1 compared to baseline.
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