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May 1, 1970British journal of surgery

Controlled trial of an anticoagulant (warfarin sodium) in the prevention of venous thrombosis following hip surgery

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Why the study?

Does prophylactic warfarin sodium prevent postoperative deep-vein thrombosis in patients over 50 years of age undergoing hip operations?

Population

n=50 consecutive patients over the age of 50 years undergoing hip operations

Comparison

Warfarin sodium given prophylactically vs Control group

Design

Cohort

Follow-up

postoperative

Authors

DPDonald PintoBristol-Myers Squibb (United States)

Discussion

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Overview

Warfarin prophylaxis did not reduce postoperative DVT in this small cohort; leaves open efficacy in hip surgery patients over 50.

Structured PICO

Does prophylactic warfarin sodium prevent postoperative deep-vein thrombosis in patients over 50 years of age undergoing hip operations?

P
Population
n=50 consecutive patients over the age of 50 years undergoing hip operations
I
Intervention
Warfarin sodium given prophylactically
C
Comparator
Control group
O
Outcome
Postoperative deep-vein thrombosis (detected by radio-isotope method, physical signs, and phlebography)hard clinical

In this small prospective study, prophylactic warfarin sodium did not appear to reduce the incidence of postoperative deep-vein thrombosis following hip surgery compared to control.

Cite This Study

Donald Pinto (1970) studied this question.

synapsesocial.com/papers/6a922bba976eaf2834c7fcb0https://doi.org/10.1002/bjs.1800570508
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Prevention of Thromboembolic Disease By Prophylactic Anticoagulation1967 · 86 citations
  2. 2Anticoagulation for Prevention of Thromboembolism Following Fractures of the Hip1966 · 100 citations
  3. 3125I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography1968 · 309 citations
  4. 4Prophylactic Anticoagulant Therapy in the Orthopedic Patient1965 · 29 citations