Key points are not available for this paper at this time.
May not yet guide warfarin timing in arthroplasty; level 5 evidence leaves open optimal initiation strategy.
The optimal strategy for postoperative Deep Venous Thrombosis (DVT) prophylaxis remains among the most controversial topics in hip and knee arthroplasty. Warfarin, the most commonly used chemical anticoagulant, initially causes transient hypercoagulability; however the optimal timing of treatment with respect to surgery remains unclear. Our purpose was to evaluate the effects of pre-versus postoperative initiation of warfarin therapy with a primary endpoint of perioperative change in hemoglobin (pre-minus post-operative level), with secondary endpoints of postoperative International Normalized Ratio (INR), drain output, and bleeding/thrombotic events.
No takes yet. Share an insight, caveat, or question.
Cara Cipriano Nicholas Erdle (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: