Key result
A two-step warfarin regimen reduced the overall incidence of venous thrombosis compared to dextran 40 (21% vs 51%) after elective hip or knee replacement, without excessive bleeding risk.
Why the study?
Does a two-step warfarin regimen prevent venous thrombosis compared to dextran 40 in patients undergoing elective total hip or knee replacement?
Population
n=100 patients at high risk for deep vein thrombosis after elective total hip or knee replacement.
Comparison
Warfarin sodium in a two-step regimen. vs Dextran 40.
Design
RCT, randomized
Authors
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Two-step warfarin may safely prevent post-arthroplasty thrombosis; leaves open efficacy versus contemporary agents in prospective trials.
RCT (n=100)
Randomized
Does a two-step warfarin regimen prevent venous thrombosis compared to dextran 40 in patients undergoing elective total hip or knee replacement?
Absolute Event Rate: 21% vs 51%
A two-step warfarin regimen provides highly effective prophylaxis against postoperative venous thrombosis after elective hip or knee replacement without excessive bleeding risk compared to dextran 40.
Charles W. Francis (1983) conducted an RCT in High risk for deep vein thrombosis after elective total hip or knee replacement (n=100). Warfarin sodium vs. Dextran 40 was evaluated on Overall incidence of venous thrombosis as documented by venography. A two-step warfarin regimen reduced the overall incidence of venous thrombosis compared to dextran 40 (21% vs 51%) after elective hip or knee replacement, without excessive bleeding risk.
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