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March 1, 1977Postgraduate Medical JournalOpen Access

A comparative study of dextran-70, warfarin and low-dose heparin for the prophylaxis of thrombo-embolism following total hip replacement

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Why the study?

Does dextran-70, warfarin, or low-dose heparin prevent deep venous thrombosis and pulmonary embolism in patients undergoing total hip replacement?

Population

Patients undergoing total hip replacement on one surgical unit

Comparison

Dextran-70, warfarin, or low-dose heparin vs Head-to-head comparison between dextran-70…

Design

RCT, randomized

Authors

HBH. M. BarberUniversity of Mississippi Medical CenterEFEdward J. FeilUniversity of BathCGC. S. B. GalaskoBoston Children's Hospital

Discussion

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Implication

Warfarin warrants consideration for pulmonary embolism prophylaxis after hip replacement; confirms superiority to dextran-70 and heparin despite equivalent calf thrombosis rates.

Structured PICO

Does dextran-70, warfarin, or low-dose heparin prevent deep venous thrombosis and pulmonary embolism in patients undergoing total hip replacement?

P
Population
Patients undergoing total hip replacement on one surgical unit
I
Intervention
Dextran-70, warfarin, or low-dose heparin
C
Comparator
Head-to-head comparison between dextran-70, warfarin, and low-dose heparin
O
Outcome
Deep venous thrombosis (calf vein thrombosis) and pulmonary embolismhard clinical

Warfarin completely prevented pulmonary embolism compared to dextran-70 and low-dose heparin in patients undergoing total hip replacement, despite similar rates of calf vein thrombosis across all groups.

Cite This Study

Barber et al. (1977) studied this question.

synapsesocial.com/papers/6a755fcfe239d27fbe032fc3https://doi.org/10.1136/pgmj.53.617.130
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of Venous Thromboembolism Following Total Hip Replacement1972 · 40 citations
  2. 2Prevention of venous thromboembolism following total hip replacement. Warfarin vs dextran 401972 · 62 citations
  3. 3Prevention of Thromboembolic Disease after Elective Surgery of the Hip1971 · 163 citations
  4. 4The Prevention of Thromboembolic Disease By Prophylactic Anticoagulation1967 · 86 citations
  5. 5Controlled trial of an anticoagulant (warfarin sodium) in the prevention of venous thrombosis following hip surgery1970 · 58 citations