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June 5, 1972JAMA

Prevention of Venous Thromboembolism Following Total Hip Replacement

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Why the study?

Does warfarin sodium prevent clinically detectable venous thrombosis or pulmonary embolism compared to dextran 40 in patients following total hip replacement?

Population

227 patients following total hip replacement

Comparison

Warfarin sodium vs Dextran 40

Design

RCT, randomized

Authors

WHWilliam H. HarrisButler University

Discussion

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Implication

Supports either agent for VTE prophylaxis after hip replacement; confirms comparable efficacy in this RCT.

Key Points

  • To compare the prophylactic efficacy and safety of warfarin sodium against dextran 40 in preventing venous thromboembolism in patients following total hip replacement.
  • Prospective randomized trial conducted in 227 patients undergoing total hip replacement.
  • Patients received thromboembolic prophylaxis with either warfarin sodium or dextran 40.
  • Thromboembolic disease occurred in 7.9% of patients receiving warfarin compared to 10% receiving dextran 40, demonstrating no statistically significant difference between arms.
  • Zero fatal pulmonary emboli occurred during the investigation.
  • Significant wound bleeding was infrequent and occurred at equal frequencies in both treatment groups.

Structured PICO

Does warfarin sodium prevent clinically detectable venous thrombosis or pulmonary embolism compared to dextran 40 in patients following total hip replacement?

P
Population
227 patients following total hip replacement
I
Intervention
Warfarin sodium
C
Comparator
Dextran 40
O
Outcome
Frequency of clinically detectable venous thrombosis or pulmonary embolismhard clinical

Warfarin sodium and dextran 40 appear equally effective and safe in providing prophylaxis against venous thromboembolic disease following total hip replacement.

Cite This Study

William H. Harris (1972) studied this question.

synapsesocial.com/papers/6a827d2fca5f0d7ba374ba10https://doi.org/10.1001/jama.1972.03200100035007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of venous thromboembolism following total hip replacement. Warfarin vs dextran 401972 · 62 citations
  2. 2A comparative study of dextran-70, warfarin and low-dose heparin for the prophylaxis of thrombo-embolism following total hip replacement1977 · 28 citations
  3. 3Thromboembolism following total hip-replacement arthroplasty. The efficicy of dextran-aspirin and dextran-warfarin in prophylaxis1976 · 32 citations
  4. 4Two-Step Warfarin Therapy1983 · 241 citations
  5. 5On thrombo-embolism after total hip replacement in epidural analgesia: A controlled study of dextran 70 and low-dose heparin combined with dihydroergotamine1984 · 35 citations