Key result
Expression of a dominant negative Cdc42 mutant inhibited contractile force and actin polymerization in response to acetylcholine stimulation in tracheal smooth muscle tissues.
Population
Tracheal smooth muscle tissues/strips
Comparison
Expression of dominant negative Cdc42 mutant via… vs Expression of wild type Cdc42
Design
Preclinical
Follow-up
2 days (incubation period)
Authors
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May modulate airway tone; hypothesis-generating in animal tissue and leaves open human translation.
Cdc42 activation regulates active tension development and actin polymerization during contractile stimulation of smooth muscle, likely via N-WASP and the Arp2/3 complex.
Tang et al. (2004) studied this question. Expression of dominant negative Cdc42 mutant (Asn-17 Cdc42) vs. Wild type Cdc42 was evaluated on Contractile force and actin polymerization in response to acetylcholine stimulation. Expression of a dominant negative Cdc42 mutant inhibited contractile force and actin polymerization in response to acetylcholine stimulation in tracheal smooth muscle tissues.
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