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September 1, 1987The FASEB Journal

Protein kinase C in the regulation of smooth muscle contraction

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Population

Smooth muscle cells (basic science review)

Design

Review

Authors

HRHoward RasmussenThe Wistar InstituteYTYoh TakuwaKanazawa UniversitySPSusanna ParkIE University

Discussion

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Implication

Challenges latch-bridge hypothesis; hypothesis-generating for PKC role in sustained contraction pending validation.

Structured PICO

P
Population
Smooth muscle cells (basic science review)
I
Intervention
Protein kinase C function and polyphosphoinositide turnover
O
Outcome
Cellular and molecular mechanisms of smooth muscle contraction

Proposes a novel coordinate fibrillar domain model for smooth muscle contraction that highlights the role of protein kinase C in the sustained tonic phase, challenging the traditional latch bridge hypothesis.

Cite This Study

Rasmussen et al. (1987) studied this question.

synapsesocial.com/papers/6a6fdcdc26a7f98052dc6fb8https://doi.org/10.1096/fasebj.1.3.3040504
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Also Consider

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