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November 1, 1992Hypertension

Protein kinase C of smooth muscle.

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Population

Smooth muscle

Design

Review

Authors

JAJ E AndreaUniversity of CalgaryMWMichael P. WalshUniversity College Dublin

Discussion

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Implication

PKC's dual role may enable selective vascular therapies; leaves open translation to hypertension management.

Structured PICO

P
Population
Smooth muscle
I
Intervention
Protein kinase C activation
O
Outcome
Smooth muscle contraction and relaxation mechanismssurrogate

Protein kinase C has a dual mechanistic role in smooth muscle, mediating both contraction and relaxation depending on its cellular localization and proteolytic state.

Cite This Study

Andrea et al. (1992) studied this question.

synapsesocial.com/papers/6a70a0cdfe4101aa97e03fffhttps://doi.org/10.1161/01.hyp.20.5.585
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1G-protein-mediated Ca2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation1991 · 322 citations
  2. 2Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase.1985 · 351 citations
  3. 3Regulation of one type of Ca 2+ current in smooth muscle cells by diacylglycerol and acetylcholine1988 · 106 citations
  4. 4Expression, purification, and characterization of protein kinase C-epsilon.1990 · 229 citations
  5. 5Calcium‐force relationships as detected with aequorin in two different vascular smooth muscles of the ferret.1985 · 158 citations