Key result
ACE2 knockout in mice exacerbated high-calorie diet-induced insulin resistance and glucose intolerance, likely via reduced GLUT4 expression and an A1-7-dependent pathway.
Population
12-week-old male ACE2 knockout (ACE2KO) mice and wild-type (WT) littermates
Comparison
Angiotensin II infusion or high-fat… vs Wild-type (WT) littermates; standard diet
Design
Preclinical
Authors
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ACE2 modulation in metabolic disease remains hypothesis-generating; animal findings should not yet inform clinical practice or human trials.
ACE2 protects against high-calorie diet-induced insulin resistance in mice, likely via transcriptional regulation of GLUT4 through an A1-7-dependent pathway.
Takeda et al. (2012) studied Insulin resistance. ACE2 knockout and high-fat, high-sucrose diet vs. Wild-type littermates was evaluated on Insulin sensitivity and glucose tolerance. ACE2 knockout in mice exacerbated high-calorie diet-induced insulin resistance and glucose intolerance, likely via reduced GLUT4 expression and an A1-7-dependent pathway.