Key result
Pre-incisional surgical site infiltration with ketamine resulted in significantly lower postoperative pain scores and better hemodynamic stability compared to ropivacaine, fentanyl, or normal saline.
Why the study?
The study evaluated the effect of pre-incisional surgical site infiltration with ketamine, fentanyl, and ropivacaine on perioperative hemodynamic parameters, pain, and adverse outcomes.
Does pre-incisional surgical site infiltration with ketamine, fentanyl, or ropivacaine improve perioperative hemodynamics and pain in patients undergoing elective lower segment cesarean section under general anesthesia?
Population
68 patients undergoing elective lower segment cesarean section under general anesthesia
Comparison
Pre-incisional surgical site infiltration with ketamine vs fentanyl vs ropivacaine vs control across four groups
Design
Surgeon-blinded study
Follow-up
24 hours
Authors
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May support ketamine infiltration for analgesia; hypothesis-generating from Level 5 evidence and requires RCT confirmation.
RCT (n=68)
Double-blind
computer-generated
No
Does pre-incisional surgical site infiltration with ketamine, fentanyl, or ropivacaine improve perioperative hemodynamics and pain in patients undergoing elective lower segment cesarean section under general anesthesia?
p-value: p=<0.05
Pre-incisional surgical site infiltration with ketamine provides better hemodynamic stability and longer postoperative pain relief compared to fentanyl or ropivacaine in cesarean sections under general anesthesia.
Mishra et al. (2021) conducted an RCT in Elective lower segment cesarean section (n=68). Ketamine surgical site infiltration vs. Ropivacaine, fentanyl, or normal saline was evaluated on Postoperative pain assessed by Visual Analog Scale (VAS) scores (p=<0.05). Pre-incisional surgical site infiltration with ketamine resulted in significantly lower postoperative pain scores and better hemodynamic stability compared to ropivacaine, fentanyl, or normal saline.
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