The Influence of Strain, Sex and Age of Mice on Infection with Plasmodium Berghei

While studying the effect of a Plasmodium berghei infection on the course of leukemia1 in mice it was noted that DBA mice and Fi hybrid mice (C57 Black 9 XDBA d) differed in their resistance to malaria. Of the many investigators who have studied P. berghei in mice, none of whom we are aware has used inbred strains. By the use of such homogeneous strains of mice, differences in the reaction to the infection might become apparent and might lead to profitable investigations concerning genetic and nongenetic influences in infection. The present report deals with the course of P. berghei infections in inbred DBA/2 and C57 Black mice and their Fi hybrids, BD Fi mice.