Key result
A local preoperative injection of triamcinolone/bupivacaine showed no significant difference in the degree of postoperative pain compared to saline in adults undergoing tonsillectomy.
Why the study?
Does a local preoperative injection of triamcinolone/bupivacaine reduce postoperative pain in adults undergoing tonsillectomy?
RCT (n=21)
Single-blind
randomized
Does a local preoperative injection of triamcinolone/bupivacaine reduce postoperative pain in adults undergoing tonsillectomy?
A preoperative local injection of triamcinolone and bupivacaine does not significantly reduce post-tonsillectomy pain compared to saline.
No pain benefit from preoperative triamcinolone/bupivacaine; does not support clinical use and confirms null effect in this RCT.
We conducted a placebo-controlled, single-blind study to determine the efficacy of a local preoperative injection of a steroid/anesthetic combination in preventing post-tonsillectomy pain. We randomized 21 adults to receive either triamcinolone/bupivacaine on the left side and saline on the right or vice versa. Injections were administered in the area of the tonsillar pillars following intubation and prior to tonsillectomy. Based on the "generalized estimating equations" model of statistical analysis, we found no significant difference in the degree of postoperative pain between the active-treatment and control sides.
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Cupero et al. (2003) conducted an RCT in post-tonsillectomy pain (n=21). triamcinolone/bupivacaine vs. saline was evaluated on degree of postoperative pain. A local preoperative injection of triamcinolone/bupivacaine showed no significant difference in the degree of postoperative pain compared to saline in adults undergoing tonsillectomy.
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