Key result
Experimental allergic encephalomyelitis in rats significantly decreased spinal cord sulphatides and gangliosides during the acute stage, and brain cerebrosides and gangliosides during recovery.
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May indicate myelin lipid disruption in acute neuroinflammation; hypothesis-generating for human MS pathology.
The content of cerebrosides, sulphatides, gangliosides, cholesterol and phospholipids was evaluated in the brain and spinal cord of rats during the acute and recovery stages of experimental allergic encephalomyelitis (EAE). During the acute stage there was a significant decrease of sulphatides and gangliosides in spinal cord; in brain, only sulphatides were diminished. In the recovery stage, cerebrosides and gangliosides were decreased in the brain, whereas the lipid content of the spinal cord was similar to that in control animals. Cholesterol esters were detected in the brain and spinal cord during both periods. The results show that the changes are not the same for brain and spinal cord during the acute and recovery stages and that glycosphingolipids from either white or grey matter seem to be preferentially altered.
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Maggio et al. (1972) studied Experimental allergic encephalomyelitis (EAE). Experimental allergic encephalomyelitis (EAE) vs. Control animals was evaluated on Lipid content (cerebrosides, sulphatides, gangliosides, cholesterol and phospholipids) in brain and spinal cord. Experimental allergic encephalomyelitis in rats significantly decreased spinal cord sulphatides and gangliosides during the acute stage, and brain cerebrosides and gangliosides during recovery.
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