Key result
Coxsackie A16 virus was isolated from 40% of tested patients during a 1968 outbreak of hand, foot and mouth disease in Japan, where all 14 cases presented with a maculopapular rash.
Observational (n=14)
No
Answers are grounded in this paper and cite their sources.
The 1968 outbreak of hand, foot and mouth disease in Northern Kyushu was confirmed to be caused by Coxsackie A16 virus through viral isolation and serological testing.
The first distinctive epidemic of hand, foot and mouth disease was reported in 1957 in Toronto, Canada and Coxsackie virus group A type 16 was implicated.Robinson, Doane and Rhodes described an illness evidently due to an A 16 Coxsackie virus in which the febrile course was marked by oral blisters and a maculopapular rash of the hands and the feet that characteristically became vesicular and to which the name “hand, foot and mouth” disease is frequently applied.Type A16 is most common, but A5 and A10 have been reported occasionally.The following is a report of 14 cases of hand, foot and mouth disease studied in the summer of 1968.Coxsackie virus A16 was isolated from four patients, with suckling mice and established green monkey kidney cell culture and serum neutralizing antibody titers to this virus were demonstrated in seven tested cases.
No takes yet. Share an insight, caveat, or question.
SHINGU et al. (1970) conducted an observational in Hand, foot and mouth disease (n=14). Coxsackie A16 virus infection was evaluated on Viral isolation and clinical characterization. Coxsackie A16 virus was isolated from 40% of tested patients during a 1968 outbreak of hand, foot and mouth disease in Japan, where all 14 cases presented with a maculopapular rash.
Synapse has enriched 10 related papers. Consider them for comparative context: