Key result
Long-term exposure to large doses of glucocorticoids, such as in Cushing's syndrome, significantly increased the PEP/ET ratio compared to healthy controls (0.391 vs 0.234, p<0.001), indicating impaired myocardial contractility.
Why the study?
Does long-term exposure to large doses of glucocorticoids impair myocardial contractility as measured by the PEP/ET ratio?
Population
270 subjects, including 217 healthy controls, 4 patients with Cushing's syndrome, 7 with primary…
Comparison
Long-term exposure to large doses of… vs Healthy controls and patients with the same…
Design
Cross-sectional
Authors
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May warrant cardiac monitoring in Cushing's patients; cross-sectional data leaves open causality and requires prospective validation.
Observational (n=266)
No
Does long-term exposure to large doses of glucocorticoids impair myocardial contractility as measured by the PEP/ET ratio?
Absolute Event Rate: 0.391% vs 0.234%
p-value: p=<0.001
Long-term exposure to large doses of glucocorticoids is associated with an increased PEP/ET ratio, suggesting impaired myocardial contractility and the potential for steroid-induced cardiomyopathy.
Akatsuka et al. (1974) conducted an observational in Adrenocortical overfunction and long-term glucocorticoid therapy (n=266). Long-term glucocorticoid exposure vs. Healthy controls or patients without steroid treatment was evaluated on PEP/ET ratio (p=<0.001). Long-term exposure to large doses of glucocorticoids, such as in Cushing's syndrome, significantly increased the PEP/ET ratio compared to healthy controls (0.391 vs 0.234, p<0.001), indicating impaired myocardial contractility.
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