Key result
Anti-U1 snRNP antibodies were identified in 60% of MRL/lpr mice (40 of 66 animals), suggesting that intact U1 particles may be targets of the immune response in this disease.
No takes yet. Share an insight, caveat, or question.
Animal data implicate U1 snRNP in murine lupus; leaves open human relevance and requires validation.
Fatenejad et al. (1994) studied Systemic Lupus Erythematosus (murine model) (n=66). Intact U1 snRNP particles was evaluated on Presence of anti-U1 snRNP antibodies. Anti-U1 snRNP antibodies were identified in 60% of MRL/lpr mice (40 of 66 animals), suggesting that intact U1 particles may be targets of the immune response in this disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: