Key result
Autoimmune human antibodies reacting with mouse retrovirus gag-p30 cross-react with a 68 Kd HnRNP protein, likely U1-RNA 68 K, due to 40% homology between the proteins.
Demonstrates cross-reactivity between human autoimmune antibodies against retroviral gag-p30 and a U1-SnRNP 68K comigrant protein.
Hypothesis-generating for retroviral triggers in autoimmunity; should not yet change clinical practice.
Using Immunoblotting procedure, we showed that autoimmune human antibodies reacting with mouse retrovirus gag-p30 also reacted with a HnRNP 68 Kd protein. Since U1-SnRNP 68 K and p30-gag proteins show 40% homology, the detected 68 Kd protein is likely to be the U1-RNA 68 K.
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Rucheton et al. (1987) studied this question. Autoimmune human antibodies reacting with mouse retrovirus gag-p30 cross-react with a 68 Kd HnRNP protein, likely U1-RNA 68 K, due to 40% homology between the proteins.
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