July 1, 1990Clinical & Experimental ImmunologyOpen Access

Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera

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Population

High- and low-titre anti-RNP-positive patient sera, mainly from patients with mixed connective tissue disease

Design

Preclinical

Authors

UNUlf NymanMalmö University ILIngrid E. LundbergUniversity of Geneva EHE HedforsKarolinska University Hospital

Discussion

Member takes

Implication

May inform epitope mapping in MCTD autoimmunity; hypothesis-generating and requires validation before clinical translation.

Structured PICO

Population

High- and low-titre anti-RNP-positive patient sera, mainly from patients with mixed connective tissue disease (MCTD)

Intervention

Recombinant fusion proteins containing different segments of the 70-kD protein

Outcome

Reactivity with human snRNP proteins and identification of antigenic regionssurrogate

The study identifies the major and minor antigenic regions of the 70-kD protein recognized by anti-RNP sera in patients with mixed connective tissue disease.

Cite This Study

Nyman et al. (1990) studied this question.

synapsesocial.com/papers/6a8c44d20ca85c7e33df3655 https://doi.org/10.1111/j.1365-2249.1990.tb05290.x

View Full Paper

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Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider