February 15, 1992The Journal of Cell BiologyOpen Access

Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K.

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Population

small nuclear RNP (snRNP) U1 particles

Design

Preclinical

Authors

BKBerthold KastnerMax Planck Institute for Multidisciplinary Sciences UKUte KornstädtPhilipps University of Marburg MBM.A. BachInstitute of Molecular Biotechnology

Discussion

Member takes

Implication

May explain distinct autoantibody profiles in SLE and MCTD; leaves open validation in human autoimmunity.

Structured PICO

Population

small nuclear RNP (snRNP) U1 particles

Intervention

Electron microscopy (EM) of complete and partially protein-deficient particles with immunoelectron microscopy employing mAbs against known components of the U1 snRNP

Outcome

Structure of the small nuclear RNP particle U1

The study maps the structural locations of U1-specific proteins A and 70K on the U1 snRNP particle, providing a potential physical basis for the distinct autoantibody profiles seen in systemic lupus erythematosus and mixed connective tissue disease.

Cite This Study

Kastner et al. (1992) studied this question.

synapsesocial.com/papers/6a81d57f5fe02a08f3d830e9 https://doi.org/10.1083/jcb.116.4.839

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Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider