Key result
Childhood cancer survivors exhibited significantly lower serum salusin β levels compared to healthy controls (p<0.001), with specific renal and cardiac dysfunctions varying by prior cancer type.
Why the study?
Childhood cancer survivors develop premature atherosclerosis and cardiovascular diseases, motivating the identification of prognostic factors of developing atherosclerosis before symptomatic CVD occurs.
Are there differences in metabolic, kidney, and heart function between childhood cancer survivors and healthy controls?
Cross-Sectional (n=141)
No
Are there differences in metabolic, kidney, and heart function between childhood cancer survivors and healthy controls?
p-value: p=<0.001
Childhood cancer survivors exhibit specific subclinical organ dysfunctions depending on their tumor type, highlighting the need for tailored long-term cardiovascular and renal follow-up.
May flag early atherosclerosis risk in childhood cancer survivors; leaves open whether targeted screening improves outcomes.
BACKGROUND: The survivors of childhood cancer suffer from a number of long-term side effects. These include atherosclerosis and cardiovascular diseases (CVDs) that develop earlier in adulthood than in the rest of the population. The aim of this study was to identify prognostic factors of developing atherosclerosis before the development of symptomatic CVD. METHODS: A total of 141 children that were 7-18 years old were examined; there were 116 survivors of childhood malignancies (hematopoietic and lymphoproliferative malignancies-52; neuroblastoma-22; Wilms tumor-24; other solid tumors-18) and 25 healthy controls. Anthropometric measurements, blood pressure measurements, ultrasonography of the abdomen, echocardiography, and laboratory tests were performed. RESULTS: There were no significant differences in gender distribution, time from the end of the treatment, weight, BMI, prevalence of central obesity, blood pressure and resistive index of the renal arteries, lipid profile, or glucose and fibrinogen levels. Patients with solid tumors had a significantly lower height and worse renal function. Patients with hematological malignancies significantly presented the lowest shortening fraction of the left ventricle. The salusin β levels were significantly higher in the control group than among the patients. CONCLUSIONS: The type and severity of side effects are closely related to the type of neoplasm and the treatment that has been undergone. Careful observation and regular follow-up are necessary.
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Janecka et al. (2023) conducted a cross-sectional in Childhood cancer survivors (n=141). Childhood cancer survivorship vs. Healthy controls was evaluated on Serum salusin β levels (p=<0.001). Childhood cancer survivors exhibited significantly lower serum salusin β levels compared to healthy controls (p<0.001), with specific renal and cardiac dysfunctions varying by prior cancer type.
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