Key result
An increased number of CAG repeats in the androgen receptor gene was associated with higher total testosterone levels and increased markers of endothelial dysfunction in men with type 2 diabetes.
Why the study?
The study was conducted to evaluate the relationship between AR gene polymorphism and parameters of carbohydrate and lipid metabolism, as well as endothelial function, in men with type 2 diabetes mellitus in a South American cohort.
Does the number of CAG repeats in the androgen receptor gene correlate with endothelial dysfunction and metabolic parameters in men with type 2 diabetes mellitus?
Cross-Sectional (n=88)
No
Does the number of CAG repeats in the androgen receptor gene correlate with endothelial dysfunction and metabolic parameters in men with type 2 diabetes mellitus?
Answers are grounded in this paper and cite their sources.
An increased number of CAG repeats in the androgen receptor gene correlates with markers of endothelial dysfunction and altered lipid metabolism in men with type 2 diabetes, suggesting its potential as a predictor for cardiovascular lesions.
Objective. The objective of the study was to study the relationship between the AR gene polymorphism and parameters of carbohydrate and lipid metabolism, as well as endothelial function in men with type 2 diabetes mellitus in a South American cohort. Materials and methods. All patients underwent a study of carbohydrate and lipid metabolism, a study of the vasomotor function of the endothelium using ultrasound of the brachial artery and the biochemical markers of endothelial dysfunction ICAM-1, VCAM-1, p-selectin, e- selectin. Results. The number of CAG repeats had a significant positive regression with the level of total testosterone, a weak negative regression of the number of CAG repeats of the AR gene are indicators of lipid metabolism: triglycerides, low-density lipoproteins, atherogenic index. Conclusion. Therefore, the number of CAG repeats of the AR receptor gene can be considered as a predictor of the development and progression of cardiovascular lesions in DM2.
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Estévez et al. (2023) conducted a cross-sectional in Type 2 diabetes mellitus (n=88). Androgen receptor gene CAG repeat polymorphism was evaluated on Correlation between the number of CAG repeats in the AR gene and total testosterone levels (r=0.687, p=0.049). An increased number of CAG repeats in the androgen receptor gene was associated with higher total testosterone levels and increased markers of endothelial dysfunction in men with type 2 diabetes.
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