Key result
Serum neopterin and beta 2-microglobulin were elevated in 11 and 9 of 16 patients with chronic myocarditis, and 2 and 5 of 11 patients with dilated cardiomyopathy, correlating with disease severity.
Population
27 patients with either dilated cardiomyopathy (DCM) (n=11) or chronic myocarditis (n=16)
Design
Cohort
Authors
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May support immune monitoring in myocarditis and DCM; hypothesis-generating pending prospective validation.
Observational (n=27)
Serum markers of cellular immune activation (neopterin and beta 2-microglobulin) correlate with disease severity and ventricular function in patients with dilated cardiomyopathy and chronic myocarditis, suggesting utility in monitoring disease development.
Fuchs et al. (1992) conducted an observational in Dilated cardiomyopathy and chronic myocarditis (n=27). Serum neopterin and beta 2-microglobulin levels was evaluated on Correlation with cardiac functional class and left ventricular functional tests. Serum neopterin and beta 2-microglobulin were elevated in 11 and 9 of 16 patients with chronic myocarditis, and 2 and 5 of 11 patients with dilated cardiomyopathy, correlating with disease severity.
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