Endocrine, Renal, and Hemodynamic Responses to Graded Dopamine Infusions in Normal Men
Key result
Graded dopamine infusions in normal men increased plasma dopamine up to 38.4 ng/ml, decreasing prolactin at all doses and increasing sodium excretion only at the highest dose.
Why the study?
What are the endocrine, renal, and hemodynamic responses to graded dopamine infusions in normal men?
Population
6 normal men
Comparison
Dopamine infusion for 2 hours at three fixed… vs Basal levels prior to infusion
Design
Other
Follow-up
2 hours per infusion
Authors
Discussion
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Member takes
Implication
Distinguishes physiological prolactin effects from supraphysiological natriuresis; leaves open translation to patients or therapeutic contexts.
Structured PICO
What are the endocrine, renal, and hemodynamic responses to graded dopamine infusions in normal men?
P
Population
6 normal men evaluated for endocrine, renal, and hemodynamic responses to graded dopamine infusions.
I
Intervention
Dopamine infusion for 2 hours at three fixed dosages (0.03 or 0.1, 0.3, and 3.0 micrograms/kg x min) on three separate occasions
C
Comparator
Basal levels prior to infusion
O
Outcome
Hemodynamic, hormonal, and natriuretic responses (including plasma dopamine, prolactin, LH, norepinephrine, sodium excretion, and heart rate)surrogate
Dopamine acutely regulates prolactin and possibly LH in normal men, but induces natriuresis only at supraphysiological concentrations.
Limitations
- GH responses were difficult to assess because of the frequency of episodic secretions.
Cite This Study
Levinson et al. (1985) studied Healthy volunteers (n=6). Dopamine vs. Basal levels was evaluated on Hemodynamic, hormonal, and natriuretic responses. Graded dopamine infusions in normal men increased plasma dopamine up to 38.4 ng/ml, decreasing prolactin at all doses and increasing sodium excretion only at the highest dose.