What question did this study set out to answer?

To determine the effects of a continuous 48-hour dopamine infusion on anterior pituitary hormone concentrations and post-infusion rebound dynamics in healthy adult males.

September 1, 1980The Journal of Clinical Endocrinology & Metabolism

Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*

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Authors

EKElaine M. KapteinUniversity of Southern California OKOscar A. KletzkyUniversity of Southern California CSCarole A. SpencerSouth Australia Pathology

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Implication

Interventional study reveals distinct patterns of anterior pituitary hormone suppression and rebound during prolonged dopamine infusion in healthy men, highlighting differential regulation of...

Key Points

To determine the effects of a continuous 48-hour dopamine infusion on anterior pituitary hormone concentrations and post-infusion rebound dynamics in healthy adult males.
Six normal adult males received a prolonged 48-hour dopamine infusion at a rate of 5 to 7.5 μg/kg·min.
Serum concentrations of prolactin (PRL), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and growth hormone (GH) were evaluated during infusion and across withdrawal periods.
Prolactin was sustainedly suppressed by 78% (P < 0.01) followed by an acute 319% rebound at 4 hours post-infusion (P < 0.01), while TSH fell 44% with a 41% rebound over 36 hours (P < 0.01).
LH and FSH initially dropped by 25% (P < 0.001) and 10% (P < 0.05), respectively, before demonstrating progressive escape during infusion and a subsequent 23% rebound (P < 0.01).
Growth hormone showed an initial transient increase followed by oscillatory spikes that significantly decreased post-infusion (P < 0.01), with an inverse correlation observed between nadir inhibition and peak rebound (r = 0.92).

Cite This Study

Kaptein et al. (1980) studied this question.

synapsesocial.com/papers/6a8923cc353a6a8ef2a5f6d8 https://doi.org/10.1210/jcem-51-3-488

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Implication

Interventional study reveals distinct patterns of anterior pituitary hormone suppression and rebound during prolonged dopamine infusion in healthy men, highlighting differential regulation of...

Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*

Discussion

Member takes

Implication

Key Points

Cite This Study

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