Key result
In situ hybridization using a novel probe mapped all three detectable endogenous genomes of Rous-associated virus type 0 to specific sites on chromosome 1 in chicken fibroblasts.
Population
Spafas gs- chf- chicken fibroblasts and Japanese quail cells
Design
Preclinical
Authors
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Hypothesis-generating in avian fibroblasts; leaves open evolutionary or pathogenic roles in mammalian or human genomes.
A novel in situ hybridization probe successfully mapped endogenous RAV-0 retrovirus sequences to chromosome 1 in chicken cells, suggesting evolution through gene duplication.
Tereba et al. (1979) studied this question. In situ hybridization using a structurally unique probe was evaluated on Chromosomal location of RAV-0 genomes and src gene. In situ hybridization using a novel probe mapped all three detectable endogenous genomes of Rous-associated virus type 0 to specific sites on chromosome 1 in chicken fibroblasts.
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