Key result
Epicardial adipose tissue thickness was significantly higher in overweight (1.38mm) and obese (1.57mm) children versus normal weight (0.87mm), and inversely associated with adiponectin (r=-0.485).
Why the study?
Epicardial adipose tissue thickness is suggested to play a role in cardiovascular disease and correlates with risk factors in adolescents, but its presence and associations in young overweight and obese children needed evaluation.
Is epicardial adipose tissue thickness increased in young overweight/obese children, and does a multidisciplinary treatment program affect it?
Observational (n=48)
Is epicardial adipose tissue thickness increased in young overweight/obese children, and does a multidisciplinary treatment program affect it?
Epicardial adipose tissue thickness is increased in young overweight and obese children and inversely correlates with adiponectin, suggesting its potential utility for early cardio-metabolic risk stratification.
May aid early cardiometabolic risk stratification in obese children; hypothesis-generating for outcomes and intervention effects.
Objective: Epicardial adipose tissue thickness (EATT) is suggested to play a role in the development of cardiovascular disease. In adolescents it is correlated with BMI z-score, cardiovascular risk factors, and pro- and anti-inflammatory markers. EATT of overweight/obese children was compared with EATT of normal weight peers (cross-sectional design). We investigated the association between EATT, cardiovascular risk factors and pro- and anti-inflammatory markers and the effect of a one year, multidisciplinary, treatment program on EATT in overweight/obese children (longitudinal design).Methods: EATT was measured by echocardiography (25 obese, 8 overweight and 15 normal weight children; median age 5.1 years). In the overweight/obese children blood pressure, lipid profile, glucose, insulin, high sensitive CRP, and adiponectin concentrations were measured. In overweight/obese children participating in a multidisciplinary treatment program, measurements were repeated after 4 and 12 months.Results: EATT was significantly higher in the overweight (median 1.38mm) and obese (median 1.57mm) children compared to normal weight children (median 0.87mm). Among obese children EATT was significantly inversely associated with adiponectin (r = −0.485).Conclusions: EATT is increased in overweight/obese children and is inversely associated with adiponectin. Echocardiographic measurement of EATT is easy and might serve as a simple tool for cardio-metabolic risk stratification.
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Hoek et al. (2019) conducted an observational in Obesity (n=48). Overweight and obesity vs. Normal weight was evaluated on Epicardial adipose tissue thickness (EATT). Epicardial adipose tissue thickness was significantly higher in overweight (1.38mm) and obese (1.57mm) children versus normal weight (0.87mm), and inversely associated with adiponectin (r=-0.485).
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