Key result
High IgG seroprevalence of HBoV was observed in healthy adults (94%), whereas the presence of virus-specific IgM was strongly associated with active viremia in children (42% vs 0%).
Population
375 individuals, including 24 infants with active viremia and respiratory illness, 52 young children without…
Design
Cross-sectional
Authors
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May aid pediatric HBoV diagnosis via IgM ELISA; cross-sectional data leave clinical adoption and validation open.
Cross-Sectional (n=375)
A newly established ELISA test demonstrates high IgG seroprevalence of HBoV in adults and associates IgM presence with active viremia in children, providing a valuable tool for serological diagnosis.
Lindner et al. (2008) conducted a cross-sectional in Human bocavirus (HBoV) infection (n=375). HBoV viremia vs. Individuals without detectable HBoV genomes was evaluated on Prevalence of IgG and IgM antibodies against HBoV virus-like VP2 particles. High IgG seroprevalence of HBoV was observed in healthy adults (94%), whereas the presence of virus-specific IgM was strongly associated with active viremia in children (42% vs 0%).
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