Key result
Compressed sensing-accelerated CMR reduced scan time by 79% to under 2 minutes while maintaining accurate estimation of mean pulmonary artery pressure (ICC 0.97, mean bias 0.1 mmHg) compared to conventional acquisition.
Why the study?
Non-invasive mPAP estimation by CMR 4D flow shows excellent agreement with right heart catheterization, but clinical use is limited by long scan times.
Does compressed sensing (CS)-accelerated CMR acquisition reduce scan time while preserving accuracy for estimating mean pulmonary artery pressure compared to non-CS-accelerated acquisition in patients referred for clinical CMR?
Cross-Sectional (n=51)
Blinded analysis of images
Randomized order of image analysis
No
Does compressed sensing (CS)-accelerated CMR acquisition reduce scan time while preserving accuracy for estimating mean pulmonary artery pressure compared to non-CS-accelerated acquisition in patients referred for clinical CMR?
Mean Difference: 0.2
Absolute Event Rate: 21.9% vs 21.7%
p-value: p=0.641
Compressed sensing-accelerated CMR can accurately estimate mean pulmonary artery pressure in under 2 minutes, significantly reducing scan time by 79% compared to standard sequences.
Background Non-invasive estimation of mean pulmonary artery pressure (mPAP) by cardiovascular magnetic resonance (CMR) four-dimensional (4D) flow analysis has shown excellent agreement with invasive right heart catheterization. However, clinical application is limited by relatively long scan times. Objectives The aim of this study was to evaluate the accuracy and time reduction of compressed sensing (CS) accelerated acquisition for mPAP estimation. Methods Patients (n=51) referred for clinical CMR at 1.5T or 3T underwent imaging with both a prototype CS□accelerated and a non-CS-accelerated flow sequence acquiring time-resolved multiple 2D slice phase contrast three-directional velocity-encoded images covering the pulmonary artery. Prototype software was used for blinded analysis of pulmonary artery (PA) vortex duration to estimate mPAP as previously validated. Results CS-accelerated and non-CS-accelerated acquisition showed increased mPAP in 22/51 (43%) and 24/51 (47%) patients, respectively. Mean bias for estimating mPAP between the two methods was 0.1±1.9 mmHg and the intraclass correlation coefficient was 0.97 [95% confidence interval 0.94-0.98]. Effective scan time was lower for the CS-accelerated acquisition (1 min 55 sec ± 27 sec vs 9 min 6 sec ± 2 min 20 sec, p<0.001, 79% reduction). Conclusions CS-accelerated CMR acquisition enables preserved accuracy for estimating mPAP compared to a non-CS-accelerated sequence, allowing for an average scan time of less than 2 minutes. CS-acceleration thereby increases the clinical utility of CMR 4D flow analysis to estimate mPAP.
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Abdula et al. (2023) conducted a cross-sectional in Suspected pulmonary hypertension (n=51). Compressed sensing (CS)-accelerated 4D flow CMR vs. Conventional non-CS-accelerated 4D flow CMR was evaluated on Mean pulmonary artery pressure (mPAP) estimation (MD 0.2 mmHg, p=0.641). Compressed sensing-accelerated CMR reduced scan time by 79% to under 2 minutes while maintaining accurate estimation of mean pulmonary artery pressure (ICC 0.97, mean bias 0.1 mmHg) compared to conventional acquisition.
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