Key result
Oral administration of 2 g vitamin C significantly reduced smoking-induced elevation in brachial-ankle pulse wave velocity by 59.2% compared to placebo in healthy male smokers.
Why the study?
Does oral vitamin C prevent smoking-induced acceleration of arterial stiffness in healthy male volunteers?
Does oral vitamin C prevent smoking-induced acceleration of arterial stiffness in healthy male volunteers?
Effect estimate: 59.2% reduction
Absolute Event Rate: 2.9% vs 7.1%
p-value: p=0.0002
A single 2 g oral dose of vitamin C significantly attenuates acute smoking-induced increases in arterial stiffness in healthy male smokers.
May blunt acute smoking-induced arterial stiffness; hypothesis-generating and should not yet change practice.
We have investigated whether the oral administration of vitamin C could prevent smoking-induced acceleration of arterial stiffness in healthy volunteers. Subjects were pretreated with 2 g vitamin C and their heart rate (HR), mean blood pressure (MBP), and brachial-ankle pulse wave velocity (baPWV) were measured before and after smoking. Smoking significantly increased the HR, MBP, baPWV (13, 6.4, 7.0%). Vitamin C treatment significantly reduced the smoking-induced elevation in baPWV at 0 min (- 58.5%, p = 0.0002) without affecting HR or MBP. These findings suggest that oral vitamin C treatment prevents smoking-induced acceleration in arterial stiffness through reducing endothelial dysfunction.
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Katayama et al. (2004) studied Healthy volunteers (chronic smokers) (n=17). Vitamin C vs. Placebo was evaluated on Smoking-induced elevation in brachial-ankle pulse wave velocity (baPWV) at 0 minutes post-smoking (59.2% reduction, p=0.0002). Oral administration of 2 g vitamin C significantly reduced smoking-induced elevation in brachial-ankle pulse wave velocity by 59.2% compared to placebo in healthy male smokers.
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