Myocardial Infarction in a Patient Who Smoked while Wearing a Nicotine Patch

Letters15 April 1994Myocardial Infarction in a Patient Who Smoked while Wearing a Nicotine PatchJames G. Warner, Jr., MD, EdD and William C. Little, MDJames G. Warner, Jr., MD, EdDBowman Gray School of Medicine; Winston-Salem, NC 27157Search for more papers by this author and William C. Little, MDBowman Gray School of Medicine; Winston-Salem, NC 27157Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-8-199404150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Transdermal nicotine was introduced in 1992 to treat tobacco dependence. Although the use of nicotine patches in patients with coronary artery disease is appealing, its safety is unclear. We recently treated a patient who, while wearing a nicotine patch, had an acute myocardial infarction soon after starting to smoke a cigarette.Our patient, a 47-year-old male smoker, suffered an inferior myocardial infarction in December 1991. Coronary arteriography at another institution showed a subtotal stenosis of the mid-right coronary artery and only a 50% stenosis of the left anterior descending artery. He stopped smoking and began wearing a ...References1. Benowitz NL. Pharmacologic aspects of cigarette smoking and nicotine addiction. N Engl J Med. 1988; 319:1318-30. Google Scholar2. Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989; 79:733-43. Google Scholar3. Folts JD, Gering SA, Laibly SW, Bertha BG, Bonebrake FC, Keller JW. Effects of cigarette smoke and nicotine on platelets and experimental coronary artery thrombosis. Adv Exp Med Biol. 1990; 273: 339-58. Google Scholar4. Gorsline J, Gupta SK, Dye D, Rolf CN. Steady-state pharmacokinetics and dose relationship of nicotine delivered from Nicoderm (Nicotine Transdermal System). J Clin Pharmacol. 1993; 33:161-8. Google Scholar5. Orleans CT, Ockene JK. Routine hospital-based quit-smoking treatment for the postmyocardial infarction patient: an idea whose time has come. J Am Coll Cardiol. 1993; 22:1703-5. Google Scholar Author, Article, and Disclosure InformationAuthors: James G. Warner, Jr., MD, EdD; William C. Little, MDAffiliations: Bowman Gray School of Medicine; Winston-Salem, NC 27157 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNicotine Ingestion Reduces Heart Rate Variability in Young Healthy AdultsNicotine and nicotine replacement therapyCardiovascular Adverse Events Associated with Smoking-Cessation PharmacotherapiesTransdermal Nicotine Replacement Therapy Safety in Patients with Cardiovascular DiseaseIs nicotine a key player or spectator in the induction and progression of cardiovascular disorders?Compounds found in Herbal productsNicotine replacement therapySafety profile of a nicotine lozenge compared with thatof nicotine gum in adult smokers with underlying medical conditions: A 12-week, randomized, open-label studyNicotine Replacement Therapy and Cardiovascular DiseaseSafety issues in pharmacotherapy for smoking in patients with cardiovascular diseaseSmoking CessationRisk of acute first myocardial infarction and use of nicotine patches in a general populationMiscellaneous drugs, materials, and medical devicesDose-related cardiovascular and endocrine effects of transdermal nicotine*Cardiovascular Toxicity of Nicotine: Implications for Nicotine Replacement Therapy 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.The Safety of Transdermal Nicotine as an Aid to Smoking Cessation in Patients with Cardiac DiseaseSelf-Poisoning Among Adults Using Multiple Transdermal Nicotine PatchesAcute Myocardial Infarction While Using the Nicotine PatchMiscellaneous drugs, materials, and medical devicesNicotine 15 April 1994Volume 120, Issue 8Page: 695KeywordsBloodCatecholaminesCoronary arteriesInfarctionMyocardial infarctionNicotineStable coronary artery diseaseStenosisSympathetic nervous systemThrombosis ePublished: 15 August 2000 Issue Published: 15 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...