Key result
Anthracycline-based chemotherapy in breast cancer patients was associated with a 38.1% incidence of subclinical cardiac dysfunction and a 13.6% incidence of overt cardiac dysfunction.
Why the study?
Anthracyclines play a major role in cancer treatment, but there was a need to evaluate the incidence of subclinical cardiac dysfunction associated with anthracycline-based regimens in patients with breast cancer at a tertiary care center.
What is the incidence of subclinical cardiac dysfunction associated with anthracycline-based chemotherapy in patients with breast cancer?
Observational (n=110)
No
What is the incidence of subclinical cardiac dysfunction associated with anthracycline-based chemotherapy in patients with breast cancer?
Anthracycline-based chemotherapy in breast cancer patients is associated with a high incidence (38.1%) of subclinical cardiac dysfunction even at lower cumulative doses, highlighting the need for vigilant cardiac monitoring.
Subclinical anthracycline cardiotoxicity incidence in breast cancer warrants monitoring; Level 5 data leaves optimal screening open.
Introduction: Cancer outcomes continue to improve due to earlier detection and newer targeted therapies, with anthracycline chemotherapy playing a major role in the modern era of cancer treatment. Anthracyclines are listed among the World Health Organization (WHO) model list of essential medicines. Study aimed to evaluate the incidence of the subclinical cardiac dysfunction associated with Anthracyclines based regimen in patients with breast cancer at a tertiary care center.
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Latha et al. (2019) conducted an observational in Breast cancer (n=110). Anthracycline-based chemotherapy was evaluated on Incidence of subclinical cardiac dysfunction. Anthracycline-based chemotherapy in breast cancer patients was associated with a 38.1% incidence of subclinical cardiac dysfunction and a 13.6% incidence of overt cardiac dysfunction.
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