Key result
A systematic review of 15 clinical studies identified specific cardiotoxicities, risk factors, and underlying mechanisms associated with anthracycline chemotherapy in breast cancer survivors.
Why the study?
This review was conducted to identify specific cardiotoxicity, risk factors, and underlying mechanisms of action related to anthracycline chemotherapy in breast cancer survivors.
What are the specific cardiotoxicities, risk factors, and mechanisms associated with anthracycline chemotherapy in breast cancer survivors?
Systematic Review (n=15)
What are the specific cardiotoxicities, risk factors, and mechanisms associated with anthracycline chemotherapy in breast cancer survivors?
This systematic review highlights the need for prevention and early detection of anthracycline-induced cardiotoxicity in breast cancer survivors.
May inform cardiotoxicity surveillance in anthracycline-treated breast cancer survivors; leaves open prospective validation of risk factors and mechanisms.
PROBLEM IDENTIFICATION: This review identifies specific cardiotoxicity related to anthracycline chemotherapy, specific risk factors related to increased anthracycline chemotherapy-induced cardiotoxicity, and underlying mechanisms of action of anthracycline chemotherapy-induced cardiotoxicity. LITERATURE SEARCH: PubMed®, CINAHL®, Embase®, and Web of Science were searched in May 2018 using keywords related to heart diseases, anthracycline chemotherapy, and breast cancer. DATA EVALUATION: Data were extracted, and study quality was assessed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. SYNTHESIS: 1,117 articles were identified through the literature search. After a review of the abstracts and articles, 15 clinical studies were identified for the final analysis by using exclusion and inclusion criteria. IMPLICATIONS FOR PRACTICE: Nurses should recognize the critical elements for prevention and early detection of anthracycline chemotherapy-induced cardiotoxicity.
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Lin et al. (2019) conducted a systematic review in Breast cancer (n=15). Anthracycline chemotherapy was evaluated on Cardiotoxicity. A systematic review of 15 clinical studies identified specific cardiotoxicities, risk factors, and underlying mechanisms associated with anthracycline chemotherapy in breast cancer survivors.
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