Key result
Aspirin (0.32 g) prevented cigarette smoking-induced platelet aggregate formation, resulting in a mean postsmoking platelet aggregate ratio of 0.93 compared to 0.80 without aspirin.
Why the study?
Does aspirin prevent cigarette smoking-induced platelet aggregate formation in healthy nonsmokers?
Does aspirin prevent cigarette smoking-induced platelet aggregate formation in healthy nonsmokers?
A single dose of aspirin prevents the acute reduction in platelet aggregate ratio caused by cigarette smoking in healthy individuals.
May blunt acute smoking-induced platelet changes in healthy subjects; hypothesis-generating and should not yet change practice.
• The purpose of this study was to determine whether aspirin could prevent a decrease in the platelet aggregate ratio that we previously found after cigarette smoking. Twenty healthy nonsmokers, who had not taken aspirin in the preceding seven days, smoked two tobacco cigarettes without filters during a 20-minute period. The mean platelet aggregate ratios before and after smoking were 0.91 and 0.80, respectively. When the experiments were repeated 48 hours later and seven to 18 hours after the ingestion of one tablet of aspirin (0.32 g), there was no decrease in the platelet aggregate ratio after smoking. The mean postsmoking platelet aggregate ratio after aspirin (0.93) was significantly higher than before aspirin. We conclude that aspirin prevented cigarette smoking-induced platelet aggregate formation. (Arch Intern Med141:206-207, 1981)
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J. W. Davis (1981) studied Healthy (n=20). Aspirin vs. No aspirin (baseline smoking challenge) was evaluated on Platelet aggregate ratio after smoking. Aspirin (0.32 g) prevented cigarette smoking-induced platelet aggregate formation, resulting in a mean postsmoking platelet aggregate ratio of 0.93 compared to 0.80 without aspirin.
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