Key result
Inhibiting PI 3-kinase, MEK, cSrc-family tyrosine kinase, or insulin receptor tyrosine kinase, as well as exposure to TNF-alpha, significantly diminished insulin uptake by bovine aortic endothelial cells (P<0.05).
Why the study?
Does insulin signaling within the endothelial cell regulate its uptake by bovine aortic endothelial cells?
Population
Bovine aortic endothelial cells (bAECs)
Comparison
50 nmol/l fluoroisothiocyanate-labeled insulin… vs Control conditions
Design
Preclinical
Authors
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Endothelial insulin signaling may regulate uptake; hypothesis-generating for vascular contributions to insulin resistance.
Does insulin signaling within the endothelial cell regulate its uptake by bovine aortic endothelial cells?
p-value: p=<0.05
Insulin uptake by bovine aortic endothelial cells requires intact insulin signaling pathways and is sensitive to cytokine-induced insulin resistance.
Wang et al. (2007) studied this question. Insulin signaling inhibitors and TNF-alpha vs. Control (uninhibited/unstimulated cells) was evaluated on Cellular insulin uptake (p=<0.05). Inhibiting PI 3-kinase, MEK, cSrc-family tyrosine kinase, or insulin receptor tyrosine kinase, as well as exposure to TNF-alpha, significantly diminished insulin uptake by bovine aortic endothelial cells (P<0.05).
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