Key result
Global work efficiency (GWE) was significantly and negatively correlated with Child-Pugh liver function classification in patients with hepatitis B cirrhosis (r = -0.83, P < 0.001).
Why the study?
Liver cirrhosis is closely associated with cardiac dysfunction, but the evaluation of left ventricular systolic function using non-invasive LVPSL and its correlation with liver function classification needed investigation.
Does non-invasive left ventricular pressure-strain loop (LVPSL) identify impaired left ventricular systolic function in patients with hepatitis B cirrhosis compared to healthy controls?
Observational (n=120)
No
Does non-invasive left ventricular pressure-strain loop (LVPSL) identify impaired left ventricular systolic function in patients with hepatitis B cirrhosis compared to healthy controls?
Effect estimate: r = -0.83
p-value: p=<0.001
Non-invasive left ventricular pressure-strain loop (LVPSL) can detect subclinical left ventricular systolic dysfunction in patients with hepatitis B cirrhosis, which correlates with the severity of liver dysfunction.
May detect subclinical LV dysfunction in hepatitis B cirrhosis; leaves open whether myocardial work indices track Child-Pugh class or outcomes.
Background Liver cirrhosis is closely associated with cardiac dysfunction. The aims of this study were to evaluate left ventricular systolic function in patients with hepatitis B cirrhosis by non-invasive left ventricular pressure-strain loop (LVPSL) technique, and to explore the correlation between myocardial work indices and liver function classification. Methods According to the Child-Pugh classification, 90 patients with hepatitis B cirrhosis were further divided into three groups: Child-Pugh A group (n = 32), Child-Pugh B group (n = 31), and Child-Pugh C group (n = 27). During the same period, 30 healthy volunteers were recruited as the control (CON) group. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE), were derived from the LVPSL and compared among the four groups. The correlation between myocardial work parameters and Child-Pugh liver function classification was evaluated, and the independent risk factors affecting left ventricular myocardial work in patients with cirrhosis were investigated by univariable and multivariable linear regression analysis. Results GWI, GCW and GWE of Child-Pugh B and C groups were lower than those of CON group, while GWW was higher than that of CON group, and the changes were more obvious in Child-Pugh C group (P < 0.05). Correlation analysis revealed that GWI, GCW, and GWE were negatively correlated with liver function classification to various degrees (r = −0.54, −0.57, and −0.83, respectively, all P < 0.001), while GWW was positively correlated with liver function classification (r = 0.76, P < 0.001). Multivariable linear regression analysis showed that GWE was positively correlated with ALB (β = 0.17, P < 0.001), and negatively correlated with GLS (β = −0.24, P < 0.001). Conclusions The changes in the left ventricular systolic function in patients with hepatitis B cirrhosis were identified using non-invasive LVPSL technology, and myocardial work parameters are significantly correlated with liver function classification. This technique may provide a new method for the evaluation of cardiac function in patients with cirrhosis.
No takes yet. Share an insight, caveat, or question.
Cao et al. (2023) conducted an observational in Hepatitis B cirrhosis (n=120). Hepatitis B cirrhosis severity (Child-Pugh classification) vs. Healthy volunteers was evaluated on Correlation between global work efficiency (GWE) and Child-Pugh liver function classification (r = -0.83, p=<0.001). Global work efficiency (GWE) was significantly and negatively correlated with Child-Pugh liver function classification in patients with hepatitis B cirrhosis (r = -0.83, P < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: