Key result
IGFBP-1, IGFBP-2, and IGFBP-3 were identified in human follicular fluid, and serum levels of IGF-I and IGF-II were consistently higher than follicular fluid levels at oocyte harvest.
Observational
The presence of three major serum IGFBPs in human follicular fluid suggests complex regulation of IGF in the ovary.
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Supports hypothesis-generating role of IGFBPs in ovarian regulation; does not yet inform clinical oocyte retrieval or stimulation protocols.
Giudice et al. (1990) conducted an observational in Ovarian stimulation. Follicular fluid and serum analysis was evaluated on Presence of IGFBPs in follicular fluid and levels of IGF-I and IGF-II in serum versus follicular fluid. IGFBP-1, IGFBP-2, and IGFBP-3 were identified in human follicular fluid, and serum levels of IGF-I and IGF-II were consistently higher than follicular fluid levels at oocyte harvest.