December 1, 1990Endocrinology

Insulin-Like Growth Factor Binding Protein-3 Secretion from Cultured Rat Sertoli Cells: Dual Regulation by Follicle Stimulating Hormone and Insulin-Like Growth Factor-I

View Full Paper

Ask AI

Bookmark

Population

Cultured rat Sertoli cells and peritubular cells

Design

Preclinical

Authors

Discussion

Hypothesis-generating in animal Sertoli cells; human testicular relevance and in vivo effects remain open.

Population

Cultured rat Sertoli cells and peritubular cells

Intervention

Follicle Stimulating Hormone (FSH) and Insulin-Like Growth Factor-I (IGF-I)

Outcome

Levels of IGFBP-3 and IGFBP-2 in conditioned mediumsurrogate

IGFBPs are expressed in a cell-type specific manner in the testis, with FSH and IGF-I exerting opposing effects on Sertoli cell IGFBP-3 expression.

Smith et al. (1990) studied this question.

View Full Paper

Ask AI

Bookmark